The COVID-19 is a new coronavirus infected disease in humans, causing more than 80,000 people infection in China, 50,000 people in Europe, Asia and other parts in the world. Thousands of patients lost their life and millions of people are in serious panic.

The SARS-CoV-2 and COVID-19

The epidemic situation in China has been greatly reduced and controllable. However, the current epidemic situation in the other countries is still severe. It is very important for the international communication to share the experiment in patient treatment especially in the population of solid organ transplant recipients. Therefore, we invited the well-known experts in kidney transplantation to conduct a successful remote international seminar on kidney transplantation under COVID-19 outbreak. In particular, we invited Professor Yuzawa Kenji from Japan to give a speech about the COVID-19 situation in Japan and Japanese Transplantation.

Professor Zhang Xiaodong was the Chairman of this meeting. At the beginning of the meeting, he welcomed all participants through the camera and the Internet, then he introduced the speakers.

The video meeting

As the first speaker, Professor Wu Jianyong from the first affiliated hospital of Zhejiang University gave a speech of kidney injury in kidney transplantation recipients with COVID-19 infection to talk about the organ protection in the medical treatment of kidney transplant recipients with COVID-19 infection.

Professor Wu Jianyong, the First Affiliated Hospital of Zhejiang University

The second speaker Professor Chen Gang from Wuhan Tongji Hospital also shared the graft kidney injury from COVID-19 infection and the achievements in diagnosis and treatment.

Professor Chen Gang, Wuhan Tongji Hospital

Then, Professor Wang Changxi from The First Affiliated Hospital Sun Yat-sen University gave a speech focus on the difference between the kidney injury caused by COVID-19 and other infective diseases such as influenza.

Professor Wang Changxi, the First Affiliated Hospital of Sun Yat-sen University

Professor Yuzawa Kenji from Ibaraki Higashi Hospital, Japan shared the current epidemiological studies of COVID-19 in Japan and the achievements in diagnosis and treatment including the policy of Japanese government to treat COVID-19 patients. In Japan, the COVID-19 is now under-controlled, but must be prepared.

Professor Yuzawa Kenji, Ibaraki Higashi Hospital, Japan

Professor Tian Puxun from No.1 Affiliated Hospital of Medical School, Xi’an Jiaotong University shared the experiments in the medical treatment of kidney transplant recipients with COVID-19 infection and a case report of a COVID-19 patient.

Professor Tian Puxun, No.1 Affiliated Hospital of Medical School, Xi’an Jiaotong University

Then, Professor Zhao Yong from Institute of Zoology, Chinese Academy of Sciences shared basic research about COVID-19. He analyzed the immune response of transplant recipients exposed to 2019-nCoV. The 2019-nCoV not only attack the alveolar type II cells like other coronavirus, but also attack the lymphocytes and the immune system, which caused the immune dysfunction. The disorder of immune system makes more difficult in the recover.

Professor Zhao Yong, Institute of Zoology, Chinese Academy of Sciences

Finally, the chairman summarized the meeting and made the following points:

COVID-19 is a new coronavirus infected disease in humans, which brings us great challenges situation in China, even the whole world. Professor Yuzawa Kenji has introduced the COVID-19 situation in Japan, which let us know the epidemic situation out of China is now under-controlled but must be well prepared.

During the meeting, the participants discussed susceptible population of COVID-19 and the protect methods to these people at high risk. We also talked about the mechanism of immune dysfunction such as the decreased of leukocytes. The count of leukocytes may be a potential monitor of the recover from the disease.

Generally, the organ transplant recipients are usually susceptible to infectious diseases. Therefore, the transplant recipients should be much more careful to take protective measures under this COVID-19 outbreak situation, otherwise they must face serious consequences of life threaten or organs loss. The immunosuppressants may increase the chance of infection, but also suppress the “infection storm”, that cause the major risk of patient death. Just like every cloud has a silver lining. Moderate immunosuppression may be beneficial to the patients.

At last, all of us have the confidence to defeat this epidemic situation. The key point is how to turn this challenge into an opportunity, in order to reduce the damage to humanity and accumulate experience from it to better meet new challenges in the future (inevitable from the history of human development). To defend against disease emergencies that may occur frequently in a quite certain time.



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